We investigate questions of the physiology of the cardiovascular system with theoretical approaches as well as by means of tools of molecular biology. One research focus is the renin-angiotensin-aldosterone-system (RAAS) which plays a key role in the blood pressure regulation and water and electrolyte balance in humans. We investigate mechanisms of gene regulation on the transcriptional as well as posttranscriptional level such as action of proteins and miRNAs on gene regulation. Our work contributes to the elucidation of pathophysiological mechanisms that lead to cardiovascular mortality which is the main cause of death in Europe.